Manistee is a somewhat small city located in the state of Michigan. With a population of 6,247 people and three associated neighborhoods, Manistee is the 163rd largest community in Michigan. Manistee has an unusually large stock of pre-World War II architecture, making it one of the older and more historic cities.

Also of interest is that Manistee has more people living here who work in computers and math than 95% of the places in the US.

A relatively large number of people in Manistee telecommute to their jobs. Overall, about 8.49% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Compared to the rest of the country, citizens of Manistee spend much less time in their cars: on average, their commute to work is only 17.20 minutes. This also means that noise and pollution levels in the city are less than they would otherwise be.

The population of Manistee overall has a level of education that is slightly above the US average for all US cities and towns of 21.84%. Of adults 25 and older in Manistee, 22.61% have at least a bachelor's degree.

The per capita income in Manistee in 2022 was $31,632, which is middle income relative to Michigan and the nation. This equates to an annual income of $126,528 for a family of four. However, Manistee contains both very wealthy and poor people as well.

Manistee is a somewhat ethnically-diverse city. The people who call Manistee home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Manistee residents report their race to be White, followed by Black or African-American. Important ancestries of people in Manistee include German, Polish, Irish, English, and Swedish.

The most common language spoken in Manistee is English. Other important languages spoken here include Polish and Spanish.