St. James is a very small city located in the state of Missouri. With a population of 3,929 people and two associated neighborhoods, St. James is the 175th largest community in Missouri.

Telecommuters are a relatively large percentage of the workforce: 8.12% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Being a small city, St. James does not have a public transit system used by locals to get to and from work.

The population of St. James overall has a level of education that is slightly above the US average for all US cities and towns of 21.84%. Of adults 25 and older in St. James, 22.43% have at least a bachelor's degree.

The per capita income in St. James in 2022 was $23,646, which is lower middle income relative to Missouri, and low income relative to the rest of the US. This equates to an annual income of $94,584 for a family of four. However, St. James contains both very wealthy and poor people as well.

The people who call St. James home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of St. James residents report their race to be White, followed by Asian. Important ancestries of people in St. James include German, Irish, English, French, and Italian.

The most common language spoken in St. James is English. Other important languages spoken here include Italian and Chinese.