Chillicothe is a medium-sized city located in the state of Ohio. With a population of 21,895 people and 11 associated neighborhoods, Chillicothe is the 78th largest community in Ohio.

The percentage of adults in Chillicothe who are college-educated is close to the national average for all communities of 21.84%: 20.97% of the adults in Chillicothe have a bachelor's degree or advanced degree.

The per capita income in Chillicothe in 2022 was $33,036, which is middle income relative to Ohio and the nation. This equates to an annual income of $132,144 for a family of four. However, Chillicothe contains both very wealthy and poor people as well.

Chillicothe is a somewhat ethnically-diverse city. The people who call Chillicothe home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Chillicothe residents report their race to be White, followed by Black or African-American. Important ancestries of people in Chillicothe include German, Irish, English, Scottish, and Italian.

The most common language spoken in Chillicothe is English. Other important languages spoken here include German/Yiddish and Spanish.