Chillicothe is a medium-sized city located in the state of Ohio. With a population of 21,895 people and 11 associated neighborhoods, Chillicothe is the 78th largest community in Ohio.

The education level of Chillicothe citizens, measured as those with bachelor's degrees or advanced degrees, is similar to the national average for all American cities and towns. 20.97% of adults 25 and older in Chillicothe have a college degree.

The per capita income in Chillicothe in 2022 was $33,036, which is middle income relative to Ohio and the nation. This equates to an annual income of $132,144 for a family of four. However, Chillicothe contains both very wealthy and poor people as well.

Chillicothe is a somewhat ethnically-diverse city. The people who call Chillicothe home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Chillicothe residents report their race to be White, followed by Black or African-American. Important ancestries of people in Chillicothe include German, Irish, English, Scottish, and Italian.

The most common language spoken in Chillicothe is English. Other important languages spoken here include German/Yiddish and Spanish.